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Tuesday, December 18, 2012

ScienceDaily: Top Health News

ScienceDaily: Top Health News


Insulin plus growth factor inhibitor limits vision damage in diabetic mice

Posted: 17 Dec 2012 04:06 PM PST

A new therapeutic approach to diabetes that combines insulin and an inhibitor of the epidermal growth factor (EGF) betacellulin could limit the progression of diabetic macular edema (DME), researchers report.

Hypertension traced to source in brain, triggering new paradigm for hypertension treatment

Posted: 17 Dec 2012 02:09 PM PST

A new study traces hypertension to a newfound cellular source in the brain and shows that treatments targeting this area can reverse the disease.

People with HIV hospitalized less often since combination antiretroviral drug therapy introduced

Posted: 17 Dec 2012 01:24 PM PST

People with HIV are being hospitalized in Ontario significantly less often than they were 15 years ago when combination antiretroviral drug therapy was introduced, new research has found.

Study estimates prevalence of pediatric caustic ingestion injuries

Posted: 17 Dec 2012 01:24 PM PST

The annual economic burden of pediatric caustic ingestion injuries was estimated at nearly $23 million with an estimated prevalence of injuries requiring hospitalization for 807 children in 2009.

Two cups of milk a day ideal for children's health, new research shows

Posted: 17 Dec 2012 12:27 PM PST

New research has answered one of the most common questions parents ask their doctors: How much milk should I be giving my children? The answer is two cups per day.

Chances seen rising for chikungunya outbreaks in NYC, Atlanta, Miami

Posted: 17 Dec 2012 12:27 PM PST

Global travel and climate warming could be creating the right conditions for outbreaks of a new virus in this country, according to a new computer model that predicts outbreaks of chikungunya, a painful virus transported by travelers and spread by the invasive Asian tiger mosquito, could occur in 2013 in New York City during August and September, in Atlanta from June through September, and year-round in Miami.

Scientists developing quick way to ID people exposed to ionizing radiation

Posted: 17 Dec 2012 12:27 PM PST

A new study could lead to a blood test that detects if a person has been exposed to radiation, measures their dose, and separates people suffering from inflammation injuries -- all in a matter of hours. They identified eight DNA-repair genes in human blood whose expression responses change more than twofold soon after blood is exposed to radiation.

Autoimmune disease: Retraining white blood cells

Posted: 17 Dec 2012 12:26 PM PST

Symptoms of an autoimmune disease disappeared after a team of scientists retrained the white blood cells involved using a specially engineered protein. This method is extremely promising for treating diseases such as type I diabetes and multiple sclerosis.

Genetic manipulation of urate alters neurodegeneration in mouse model of Parkinson's disease

Posted: 17 Dec 2012 12:26 PM PST

Investigators report that mice with a genetic mutation increasing urate levels were protected against the kind of neurodegeneration that underlies Parkinson's disease, while the damage was worse in animals with abnormally low urate. Their findings add further support to the possibility that increasing levels of urate may protect against Parkinson's disease.

New immune therapy successfully treats brain tumors in mice

Posted: 17 Dec 2012 12:26 PM PST

Using an artificial protein that stimulates the body's natural immune system to fight cancer, a research team has engineered a lethal weapon that kills brain tumors in mice while sparing other tissue. If it can be shown to work in humans, it would overcome a major obstacle that has hampered the effectiveness of immune-based therapies.

Radio waves to kidneys lower persistent high blood pressure

Posted: 17 Dec 2012 12:25 PM PST

A minimally invasive procedure lowered blood pressure in patients whose condition failed to respond to medication. Catheter-based renal denervation was found to be safe and effective in lowering blood pressure up to one year after starting treatment, and did not show any lasting harm to the kidneys or heart. The procedure ultimately may offer a new treatment alternative for reducing high blood pressure, a global public health epidemic.

Rise in New Jersey autism prevalence documented in new study

Posted: 17 Dec 2012 12:25 PM PST

In a study of 58 communities in four New Jersey counties, autism spectrum disorder (ASD) prevalence is found to have risen from 10.6 per thousand in 2002, to 17.4 per thousand in 2006.

Hybrid tunnel may help guide severed nerves back to health

Posted: 17 Dec 2012 11:07 AM PST

Building a tunnel made up of both hard and soft materials to guide the reconnection of severed nerve endings may be the first step toward helping patients who have suffered extensive nerve trauma regain feeling and movement, according to a biomedical engineers.

Chronic worriers at higher risk for PTSD, research finds

Posted: 17 Dec 2012 11:07 AM PST

People who worry constantly are at greater risk for post-traumatic stress disorder, according to new research.

New technology may enable earlier cancer diagnosis: Nanoparticles amplify tumor signals, making them much easier to detect in urine

Posted: 17 Dec 2012 11:07 AM PST

Finding ways to diagnose cancer earlier could greatly improve the chances of survival for many patients. One way to do this is to look for specific proteins secreted by cancer cells, which circulate in the bloodstream. However, the quantity of these biomarkers is so low that detecting them has proven difficult. A new technology may help to make biomarker detection much easier. Researchers have developed nanoparticles that can home to a tumor and interact with cancer proteins to produce thousands of biomarkers, which can then be easily detected in the patient's urine.

New window on Parkinson's disease: Metallic probe proves able to detect fibrils from misfolded proteins in real time

Posted: 17 Dec 2012 11:06 AM PST

Scientists discover a new molecular probe to track aggregated fibroids inside living cells that cause Parkinson's disease.

To revert breast cancer cells, give them the squeeze

Posted: 17 Dec 2012 11:05 AM PST

Researchers have found that compression can guide malignant breast cells back to a normal growth pattern. The findings demonstrate the influence of mechanical forces on a cell's destiny.

Re-engineered optogenetic switches allow direct measurement of complex cellular systems

Posted: 17 Dec 2012 11:05 AM PST

A chemical biology lab has re-engineered optogenetic switches so that switches run backward, firing bursts of fluorescent light that reveal newly detailed patterns of electrical activity in neural networks, beating cardiac cells and developing embryos.

Immune cells use tethered slings to avoid being swept away

Posted: 17 Dec 2012 11:05 AM PST

Neutrophils, critical components of the immune system's response to bacteria and other pathogens, throw out tube-like tethers that act as anchor points, controlling their speed as they roll along the walls of blood vessels during extremely fast blood flow en route to an infection site.

Fitting 'smart' mobile phone with magnifying optics creates 'real' cell phone

Posted: 17 Dec 2012 11:05 AM PST

By fitting a "smart" mobile phone with magnifying optics, researchers created a real "cell" phone. a diagnostic-quality microscope for clinics in developing countries as well as American biology classrooms.

Rare, lethal childhood disease tracked to failure to degrade nerve cells' filaments

Posted: 17 Dec 2012 11:05 AM PST

A defective protein explains why a failure in protein degradation would lead to the massive aggregations of a class of filaments that disrupt the functioning of neurons of children with the rare, untreatable genetic disease giant axonal neuropathy. Discovery may have implications for more common types of neurodegenerative diseases such as Alzheimer's.

Changes in progenitor cell population in breast may be overlooked factor in breast cancer

Posted: 17 Dec 2012 11:05 AM PST

DNA mutations that accumulate as women age are not the sole contributor to higher frequency of breast cancer in women over 50. In breast cancer and aging, changes in the populations of progenitor cells in breast tissue may be a powerful and until now overlooked factor.

Neurons die in Alzheimer's because of faulty cell cycle control before plaques and tangles appear

Posted: 17 Dec 2012 11:05 AM PST

The two infamous proteins, amyloid-beta and tau, that characterize advanced Alzheimer's disease, start healthy neurons on road to cell death long before appearance of deadly plaques and tangles by working together to reactivate supposedly blocked cell cycle in brain cells, according to new research.

Novel role for protein linked to obesity and development of type 2 diabetes identified

Posted: 17 Dec 2012 11:04 AM PST

Researchers have taken another step toward better understanding the metabolic functions of obesity and its connection to type 2 diabetes.

New form of cell division found: Natural back-up mechanism during faulty cell division

Posted: 17 Dec 2012 11:03 AM PST

Researchers have discovered a new form of cell division in human cells. They believe it serves as a natural back-up mechanism during faulty cell division, preventing some cells from going down a path that can lead to cancer.

Regulator of healthy life span uncovered

Posted: 17 Dec 2012 09:14 AM PST

A new series of studies in mouse models uncovered that the aging process is characterized by high rates of whole-chromosome losses and gains in various organs, including heart, muscle, kidney and eye, and demonstrate that reducing these rates slows age-related tissue deterioration and promotes a healthier life span.

Perceived stress may predict future coronary heart disease risk

Posted: 17 Dec 2012 09:14 AM PST

Are you stressed? Results of a new meta-analysis of six studies involving nearly 120,000 people indicate that the answer to that question may help predict one's risk of incident coronary heart disease (CHD) or death from CHD.

New molecule linked to late-stage breast cancer

Posted: 17 Dec 2012 09:14 AM PST

Researchers have identified a molecule linked to more aggressive forms of breast cancer -- a discovery that could point the way to potential cures.

Muscle weakness in Down syndrome: New study offers insights

Posted: 17 Dec 2012 09:14 AM PST

Study led by researchers at Syracuse University offers insights into role of muscle weakness in Down syndrome.

Tourette syndrome and other tic disorders in children

Posted: 17 Dec 2012 08:06 AM PST

More than one in every ten schoolchildren suffers from a transient tic disorder, and 1% have a particular type of tic disorder known as Tourette syndrome. Researchers report on various modes of diagnosis and treatment for these disorders.

Role of oxidative stress in diseases needs to be re-evaluated: Preventive detention for oxidizing agents

Posted: 17 Dec 2012 07:26 AM PST

Oxidative stress is believed to cause a number of diseases. Up to now, it has been common practice to measure oxidative stress levels by determining the oxidation state of a small molecule called glutathione in cell extracts. Scientists have now discovered that cells under stress deposit their oxidized glutathione in a cellular waste repository. This protects cells from oxidative stress – and questions the validity of the conventional measuring method.

Brain imaging identifies bipolar disorder risk in adolescents

Posted: 17 Dec 2012 07:26 AM PST

Australian researchers have used brain imaging technology to show that young people with a known risk of bipolar (but as yet have no signs of the condition) have clear and quantifiable differences in brain activity when compared to controls.

Genetic defect in sex cells may predispose to childhood leukemia

Posted: 17 Dec 2012 07:25 AM PST

Researchers have found a possible heredity mechanism that predisposes children to acute lymphoblastic leukemia (ALL), the most common type of blood cancer in children. The presence of a genetic defect in the egg or sperm from which children having ALL arise may be a prerequisite for the disease to develop.

Biological pathway that controls the leakiness of blood vessels unraveled

Posted: 17 Dec 2012 07:25 AM PST

Scientists have decoded the entire pathway that regulates leakiness of blood vessels — a condition that promotes a wide number of disorders, such as heart disease, cancer growth and spread, inflammation and respiratory distress.

Why are kids in asthma hotspots in NYC more likely to visit the ER? Exercise may be a factor

Posted: 17 Dec 2012 06:15 AM PST

Asthmatic children living in asthma hotspots in New York City were twice as likely to have experienced symptoms after exercise and more likely to have visited their doctor in a hurry or an ER because of breathing problems.

Mechanism used by BRCA1 to suppress tumors uncovered

Posted: 17 Dec 2012 06:15 AM PST

A new reveals how a well-known tumor suppressor gene may be functioning to stop cancer cell growth. The findings focus on the gene BRCA1.

Snack attack: Eating unhealthy snack foods may affect cancer risk in patients with Lynch syndrome

Posted: 17 Dec 2012 06:15 AM PST

A new analysis has found that loading up on snack foods may increase cancer risk in individuals with an inborn susceptibility to colorectal and other cancers. The study suggests that an eating pattern low in snack foods could help these individuals -- who have a condition called Lynch syndrome -- lower their risk.

New technology allows scientists to capture and preserve cancer cells circulating in the bloodstream

Posted: 17 Dec 2012 06:15 AM PST

Scientists have developed a new nanoscale Velcro-like device that captures and releases tumor cells that have broken away from primary tumors and are circulating in the bloodstream. This new nanotechnology could be used for cancer diagnosis and give insight into the mechanisms of how cancer spreads throughout the body.

Worries about dementia: How hospitalization affects the elderly

Posted: 17 Dec 2012 06:13 AM PST

Older people often worry about dementia and while some risks are known, for example alcoholism or stroke, the effects of illness are less clear. New research looks at illness requiring hospitalization and treatment in the intensive care unit (ICU) and finds that infection or severe sepsis, neurological dysfunction, such as delirium, or acute dialysis are all independently associated with an increased risk of a subsequent diagnosis of dementia.

Reproduction and life span are intertwined

Posted: 17 Dec 2012 06:11 AM PST

Removing a roundworm's germ cells prolongs the animal's life. The gonad is well known to be important for reproduction but also affects animal life span. Removal of germ cells – the sperm and egg producing cells – increases longevity of the roundworm Caenorhabditis elegans. However, the underlying molecular mechanisms were a mystery. Now scientists have discovered that germ cell removal flips a "molecular switch" that extends the life span by using components of a "developmental clock".

Achilles' heel of pathogenic bacteria discovered

Posted: 17 Dec 2012 06:11 AM PST

Multidrug-resistant bacteria remain a major concern for hospitals and nursing homes worldwide. Propagation of bacterial resistance is alarming and makes the search for new antimicrobials increasingly urgent. Scientists have now identified a potential new target to fight bacteria: the factor EF-P. EF-P plays a crucial role in the production of proteins that are essential for the virulence of EHEC or salmonellae. The researchers' findings suggest that drugs blocking EF-P would impair the fitness of pathogenic bacteria and might lead to a new generation of specific antibiotics that allow to combat infections caused by drug-resistant pathogens.

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